The 12-Factor Agents framework adapts the proven 12-factor app principles to the unique demands of AI Agent development. It prescribes a single codebase with version control, explicit dependency declaration, environment-agnostic configuration, and seamless integration with external services. It defines clear build and release stages, supports stateless processes, port-based binding, process concurrency, graceful shutdowns, and parity between development and production. Centralized logging and scripted administrative tasks are also emphasized. By following these structured guidelines, development teams can create AI Agents that are modular, scalable, and resilient, simplifying deployment, enhancing observability, and reducing operational complexity.