OSU NLP Middleware is a lightweight framework built in Python that simplifies the development of AI agent systems. It provides a core agent loop that orchestrates interactions between natural language models and external tool functions defined as plugins. The framework supports popular LLM providers (OpenAI, Hugging Face, etc.), and enables developers to register custom tools for tasks like database queries, document retrieval, web search, mathematical computation, and RESTful API calls. Middleware manages conversation history, handles rate limits, and logs all interactions. It also offers configurable caching and retry policies for improved reliability, making it easy to build intelligent assistants, chatbots, and autonomous workflows with minimal boilerplate code.